The huge amounts of data acquired from PolyOmics technologies can only be handled with intensive bioinformatics support that has to provide an adequate data management, efficient data analysis algorithms, and user-friendly software applications. The Bioinformatics Resource Facility (BRF) as part of the Technology Platform Bioinformatics at the Center for Biotechnology (CeBiTec) can look back on many years of expertise on the development of innovative bioinformatics software applications, in which design and implementation are driven by close collaborations with researchers of the center. Within many projects, experimental data are produced by the CeBiTec Technology Platform Genomics and it is therefore one of our major goals to simplify and automate the subsequent steps for a systematic data processing and analysis as far as possible. For the development of larger software platforms we follow the design principle to build specialized tools for separate scopes that can be interlinked to integrate the various data resources. Technically, we can rely on an extensive hardware infrastructure that provides all necessary storage and compute capacities.