CeBiTec Colloquium (non-scheduled)
| date | Tuesday, August 3rd 2010, 17 c.t. | |
| location | G2-104, CeBiTec Building | |
| speaker | Prof. Dr. Reingard GrabherrCD-Laboratory for Genetically Engineered Lactic Acid Bacteria | |
| title | Tools for Genetic Engineering of Industrial Lactic Acid Bacteria | |
| Lactic acid bacteria (LAB) are aero-tolerant, anaerobic, Gram-positive, acid-tolerant and non-spore-forming bacteria. LAB are important industrial microbes, mostly associated with food production such as preservation by acidification or for improving flavour and texture. Also silage fermentation in order to refine and preserve crops and plant material depends on LAB producing lactic acid from water-soluble carbohydrates. To date, much effort is put into genetic engineering of various, mostly dairy derived LAB strains, for the purpose of protein production and delivery of oral vaccines. Our goal is to further contribute to functional genome-wide analysis of industrial LAB, to build upon these data and to develop a molecular tool box for genetic engineering and improvement of catabolic and anabolic performances. Genome sequencing, promoter studies, characterisation of plasmids and enzyme engineering serves to understand and modify LAB in order to improve and extend their performance in different applications. Specific targets are silage processes (animal feed), preservation of alternative substrates (e.g. leaves for biogas reactors), and development of efficient host-vector systems for the production of recombinant proteins. | ||
| host | Prof. Dr. Alfred Pühler |