Vortrag: 2008/11/11 Dr. Francisco Soriano, Department of Medical Microbiology and Antimicrobial Chemotherapy Fundación Jiménez Díaz, Madrid, Spain

2008/11/11, 17:15

CeBiTec Laboratory Building, Room G2-104

The International NRW Graduate School in Bioinformatics and Genome Research invites to a talk and colloquium:

Research in Microbiology: From the bedside to the genome and vice versa

Abstract:

In vitro and animal studies performed at our laboratory demonstrated that Corynebacterium urealyticum fulfils all the Koch's postulates for considering it the etiological agent of urinary diseases, mainly encrusted cystitis and pyelitis. We still consider Koch's postulates as a cornerstone to define bacterial causality. In 2008, Tauch et al. completely sequenced the C. urealyticum genome, deducing the lifestyle of this pathogen and "turning" from the genome (basic research) to the bedside. The knowledge of the C. urealyticum genome explains its lipophilia (ecology), adherence to host tissues and evasion of the immune system (pathogenicity and virulence), role of urease (stone formation), and antimicrobial resistance. Furthermore, such advances achieved by many investigators from this University in conjunction with Roche Applied Science, open new and promising perspectives, i.e. the application of bacterial interference, use of bacteriocins to prevent colonization, development of drugs against bacterial adherence and biofilm formation, recognition of new targets for new antimicrobials, development of new anti-urease drugs, new methods for rapid diagnosis and vaccine development.