New catalytic reactions by directed enzyme evolution
Our research group combines methods from organic chemistry, computational modelling and directed evolution to design, apply and understand new enzyme function.
Jun.-Prof. Dr. Stephan Hammer
Previous and Current Research
Due to their finely tunable macromolecular structure, enzymes provide significant advantages for catalyst development. Multiple catalyst-substrate interactions in enzyme active sites help to distinguish between competing transition states through conformational control of substrates and reactive intermediates. Accordingly, sought-after chemical transformations that have so far eluded catalysis might be accessible in engineered enzymes.
Future Projects and Aims
We aim to develop a new class of catalysts for synthetic organic chemistry that is protein-based, fully genetically encoded and catalyzes fundamental C-C, C-N and C-O bond formations that do not have a good catalytic solution. These new enzymes will be applied in organic synthesis, increase our understanding in enzymology and can expand the metabolism in living organisms.