| date | | Friday, December 18th 2009, 10 c.t. |
| location | | G2-104, CeBiTec Building |
| speaker | | Dr. Joris MessensDepartment of Molecular and Cellular Interactions, Vlaams Instituut voor Biotechnologie (VIB), Vrije Universiteit Brussel, Belgium |
| title | | The unexplored mycothiol/mycoredoxin redox pathway of Mycobacterium tuberculosis |
| | | Members of Actinobacteria are Gram-positive bacteria encountered in a wide range of ecosystems and are known to cause important human diseases, such as tuberculosis, leprae and Johne’s disease in ruminants. One of the features common to most Actinobacteria is the production of mycothiol, a small thiol that is often present in millimolar amounts and that has analogous redox homeostasis function to glutathione. I will focus on the mycothiol/mycoredoxin reduction pathways in Actinobacteria and on the evaluation of these pathways as possible targets against Mycobacterium tuberculosis. Further, I will show how arsenate reductases are coupled to different thiol mechanisms, and how we identified arsenate reductase of Corynebacterium glutamicum as the first enzymes using mycothiol and mycoredoxin in a thiol/disulfide redox cascade. |
| host | | Dr. Jörn Kalinowski |
