Natural products have been and continue to be of tremendous importance for human health purposes. They have captivated researchers for decades with their remarkable structural complexity, bioactivity, and the intricate enzymatic reactions underlying their biosynthesis. While much attention has been focused on traditional classes such as non-ribosomal peptides, polyketides, and terpenoids, our research program specifically aims to expand upon these systems by uncovering and investigating distinct specialized metabolic pathways to unlock access to truly novel chemical entities and the associated enzyme-catalyzed chemical transformations.

The talk will focus on our ongoing endeavors in exploration of non-canonical SAM-derived enzyme chemistry by combining genomics-driven computational methods with functional, structural, and mechanistic investigations.