| date | | Monday, February 21st 2011, 17 c.t. |
| location | | G2-104, CeBiTec Building |
| speaker | | Dr. Ralf SteuerInstitut für theoretische Biologie, umboldt-Universität zu Berlin
|
| title | | From stoichiometry to kinetics of biochemical pathways:
Towards a computational model of the cyanobacterium Synechocystis sp. PCC 6803 |
| | | One of the goals of current molecular biology is to describe and analyse cellular metabolism and its regulation, with manifold application in biotechnology and medical research. To facilitate this task, the utilization of computational tools and mathematical models is indispensable. The talk will describe a number of computational approaches towards a computational description of metabolism. Our focus are intermediate methods that aim to bridge the gap between stoichiometric analysis and detailed kinetic models of cellular pathways. In particular, it is shown that it is possible to acquire a detailed and quantitative picture of the possible dynamics of metabolic systems without assuming detailed knowledge of the underlying rate equations and parameters. Applications and examples are based on the research initiative FORSYS-Partner “Cyanobacterial biofuel production” that aims at a targeted modification of metabolism to produce fuels directly from photosynthetic microorganisms. The focus of our project is Synechocystis sp. PCC 6803, a model organism for the study of photosynthetic and metabolic processes and their regulation. |
| host | | Prof. Dr. Olaf Kruse
|
