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Metabolic Engineering of Unicellular Systems and Bioproduction

Microorganisms, unicellular algae, and mammalian cell lines are applied for the production of a broad spectrum of valuable products. These include the sustainable production of bioproducts with microorganisms (monomers for biopolymers, secondary metabolites, amino acids and proteins, especially enzymes), the production of recombinant therapeutic and diagnostic proteins in animal cell lines, studies of plant growth and development, the optimisation of the sunlight-to-biomass conversion in phototrophic microorganisms, the production of biofuels with heterotrophic and phototrophic organisms, and the protein production and secretion as well as the synthesis of hydrocarbon compounds and the biocatalytic H2 production with microalgae.

Speakers: Prof. Dr. O. Kruse and Prof. Dr. S. Hammer


Selection of current projects

  • cassaFLOW - Cascades for Stereoselective Synthesis of Amino Acids
    Responsible: Prof. Dr. H. Gröger
    Funded by: European Commission
  • CO2BioTech: Limerick - Kalkstein - eine essenzielle Resource für Zement treibt einen neuen Polyamid Zyklus an
    Responsible:
    Prof. Dr. V. Wendisch
    Funded by: Federal Ministry of Education and Research (BMBF)
  • Die dynamische Funktion der Typ II-Peroxiredoxine B/C/D als Redoxsensoren im Redox-regulatorischen Netzwerks des Cytosols
    Responsible: Prof. Dr. K.-J. Dietz
    Funded by: German Research Foundation (DFG)
  • Flavin-abhängige Halogenasen – Von der Cofactor-Regenerierung bis zu komplexen Substraten
    Responsible: Prof. Dr. N. Sewald
    Funded by: German Research Foundation (DFG)
  • FluPepDye: Entwicklung neuer peptid-basierter NIR-Sondenkonjugate zum spezifischen und selektiven Nachweis früher Amyloid-Biomarker
    Responsible: Prof. Dr. N. Sewald
    Funded by: German Research Foundation (DFG)
  • IBÖM07: Bio-Polyole-II - Bio-Polyole für Hochleistungsverbundwerkstoffe aus heimischen Pflanzenölen
    Responsible: Prof. Dr. H. Gröger
    Funded by: Federal Ministry of Education and Research (BMBF)
  • iCulture: A digital bio-platform and co-culture bioprocess to prospect and utilize macroalgae responsibly and sustainably
    Responsible: Prof. Dr. V. Wendisch
    Funded by: European Commission
  • Innovation Campus for Sustainable Solutions - InCamS@BI
    Responsible: Prof. Dr. H. Gröger
    Funded by: Federal Ministry of Education and Research (BMBF)
    LinkedIn: https://www.linkedin.com/company/incamsbi/
  • Maßgeschneiderte Inhaltsstoffe 2-2 - Verbundvorhaben: ForceYield 2.2 - An advanced microbial platform for high-yield production of biochemicals from agricultural sidestreams
    Responsible: Prof. Dr. V. Wendisch
    Funded by: Federal Ministry of Education and Research (BMBF)
  • Maßgeschneiderte Inhaltsstoffe 2-2 - Verbundvorhaben: PepMetal 2.2 - Verbundvorhaben: Entwicklung eines Systems für das Design und die Synthese von maßgeschneiderten Peptiden für die Behandlung von Polymeren im Vorfeld der Kunststoff-Metallisierung
    Responsible: Prof. Dr. J. Kalinowski
    Funded by: Federal Ministry of Education and Research (BMBF)
  • Mikroalgen als nachhaltige Rohstoffe zur biologischen, heterotrophen Herstellung von Feinchemikalien
    Responsible: Prof. Dr. O. Kruse
    Funded by: Federal Ministry of Food and Agriculture (BMEL)
  • Mini6Ei - Geschlechtserkennung bei sechstägigen Bruteiern mittels zeitaufgelöster Fluoreszenzspektroskopie
    Responsible: Prof. Dr. K. Niehaus
    Funded by: Federal Ministry of Food and Agriculture (BMEL)
  • MONOWAX: Exploring the potential of oleaginous microalgae Monoraphidium neglectum for wax ester production
    Responsible: Prof. Dr. O. Kruse
    Funded by: European Commission
  • Nachwuchsgruppe Emmy Noether-Programm - Entwicklung neuer katalytischer Reaktionen durch gerichtete Evolution Protein-basierter Katalysatoren
    Responsible: Jun.-Prof. Dr. S. Hammer
    Funded by: German Research Foundation (DFG)
  • Regulation der Synthese und Funktion der 12-Oxophytodiensäure in der zellulären Signalverarbeitung der Pflanze
    Responsible: Prof. Dr. K.-J. Dietz & Prof. Dr. H. Gröger
    Funded by: German Research Foundation (DFG)
  • Späte Diversifizierung von Peptiden durch Übergangsmetall-katalysierte Kreuzkupplungen
    Responsible: Prof. Dr. N. Sewald
    Funded by: German Research Foundation (DFG)
  • SUN-PERFORM: Synthetic biology United with Nanotechnology – A Biohybrid Approach to Improve Light-harvesting and CO2 Fixation for High Performance Sustainable Solar Fuel Production
    Responsible: Prof. Dr. Olaf Kruse
    Funded by: European Commission
  • Untersuchung der Mechanismen von Kohlenstoffdioxid-Sensing und Signaltransduktion bei der Antwort der Mikroalge Chlamydomonas reinhardtii auf Kohlenstoffdioxid-Mangel
    Responsible: Prof. Dr. Olaf Kruse
    Funded by: German Research Foundation (DFG)
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