Metabolic Engineering of Unicellular Systems and Bioproduction
Microorganisms, unicellular algae, and mammalian cell lines are applied for the production of a broad spectrum of valuable products. These include the sustainable production of bioproducts with microorganisms (monomers for biopolymers, secondary metabolites, amino acids and proteins, especially enzymes), the production of recombinant therapeutic and diagnostic proteins in animal cell lines, studies of plant growth and development, the optimisation of the sunlight-to-biomass conversion in phototrophic microorganisms, the production of biofuels with heterotrophic and phototrophic organisms, and the protein production and secretion as well as the synthesis of hydrocarbon compounds and the biocatalytic H2 production with microalgae.
Speakers: Prof. Dr. V.F. Wendisch and Prof. Dr. N. Sewald
Selection of current projects
- Die Integration der Thiolschalter Cyclophilin 20-3 und 2-Cystein Peroxiredoxin in das Redox-regulatorische Netzwerk
Responsible: Prof. Dr. K.-J. Dietz
Funded by: German Research Foundation (DFG) - Biotechnologisches Produktionsverfahren zur industriellen Herstellung von Fettnitrilen aus Fetten, Ölen und deren Derivaten (Fettnitrile)
Responsible: Prof. Dr. H. Gröger
Funded by: Funded by: Federal Ministry of Food and Agriculture (BMEL) - STREPSYNTH ? Rewiring the Streptomyces cell factory for cost-effective production of biomolecules
Responsible: Prof. Dr. J. Kalinowski
Funded by: European Commission (EU FP 7) - Genetische Modifizierung von Actinoplanes sp. Wildtyp und Produktionsstämmen zur Optimierung der Acarviosyl-Maltose-Biosynthese
Responsible: Prof. Dr. J. Kalinowski, Prof. Dr. A. Pühler
Funded by: industrial partner - MERIT – Microalgae as renewable innovative green cell factories
Responsible: Prof. Dr. O. Kruse
Funded by: ERA-CoBioTech - FSAC – Fettsäure-sekretierende Algen
Responsible: Prof. Dr. O. Kruse
Funded by: Federal Ministry of Education and Research (BMBF) - Elucidating the regulatory network of light harvesting in photoheterotrophic microalgae
Responsible: Prof. Dr. O. Kruse
Funded by: German Research Foundation (DFG) - Wasseroxidationskatalyse mit biomimetischen Mangankomplexen gekoppelt mit artifiziellen und biologischen Lichtsammelantennen
Responsible: Prof. Dr. O. Kruse
Funded by: Federal Ministry of Education and Research (BMBF) - PHOTOFUEL – Developing next generation technologies for biofuels and sustainable alternative fuels
Responsible: Prof. Dr. O. Kruse
Funded by: European Commission (EU Horizon 2020) - Gezielte Optimierung der Xanthanproduktion in Xanthomonas campestris Wildtyp- und Produktionsstämmen
Responsible: Prof. Dr. A. Pühler, Prof. Dr. K. Niehaus
Funded by: Industral Partner - CLIB-Kompetenzzentrum Biotechnologie (CKB)
Responsible: Prof. Dr. V.F. Wendisch
Founded by: EFRE-NRW - INDIE – Biotechnological production of sustainable indole
Responsible: Prof. Dr. V.F. Wendisch
Funded by: ERACoBioTech, BMELV/FNR - Direct utilization of agroresidual biomass for the production of alpha,omega-diamines as well as omega-amino acids:
strain and process development using Corynebacterium glutamicum
Responsible: Prof. Dr. V.F. Wendisch
Funded by: BMBF-IB - Wertschöpfung aus pilzlichen Fermentationsabfällen durch Herstellung von Feinchemikalien
Responsible: Prof. Dr. V.F. Wendisch
Funded by: Fereral Ministry for Economic Affairs and Energy (BMWi)